Serotonin is used by the brain as a messenger. We do know that each of these medications affect a chemical in the brain called serotonin. The good news is that after decades of research, we know how to treat patients, even though we do not know exactly why our treatments work. It remains unclear as to how these particular drugs help OCD. Drugs work very differently for each person. Remember! It is important not to give up after failing one or two drugs. The only way to tell which drug will be the most helpful with the least side effects is to try each drug for about 3 months. However, for any given patient, one drug may be very effective, and the others may not. Whenever any of the above drugs have been studied head to head, there seems to be no significant difference in how well they work. venlafaxine (Effexor®) – up to 375 mg/day.escitalopram (Lexapro®) – up to 40 mg/day.clomipramine (Anafranil®) – up to 250 mg/day.citalopram (Celexa®) – up to 40 mg/day*.sertraline (Zoloft®) – up to 200 mg/day.
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